The project is integrated into the SRIA 008-Action1 consortium, which investigates the role of the immune system in farm animals. The overall objectives of the consortium are i) to improve understanding of the early development of a robust immune system; ii) to identify new biomarkers for immune protection using cutting-edge technologies; iii) to increase understanding of the mechanisms that trigger protective immunity at the site of pathogen entry; iv) to investigate the effect of adjuvants for specific types of vaccines; and v) to identify external and internal factors that are important for the immune response triggered by vaccines. Our contribution focuses on the immune system and immune response in pigs. We aim to evaluate the immune status in relation to age and develop robust pipelines for investigating the effect of pig vaccines and immunostimulants on innate immunity. Using multiplex single-cell approaches and modern analytical tools, the innate single-cell immunome will be mapped and vaccine-induced epigenetic changes under the control of specific T-cell subpopulations will be identified.

Project participants from FLI:

Prof. Dr. Anca Dorhoi
PD Dr. Robert Kammerer
Andrei Lazar