Mobile livestock farmers (MLFs) or pastoralists remain key partners in efforts to control transboundary animal diseases (TADs) in Africa due to their seasonal mobility to maintain adequate feeding resources for their livestock and avoid conflicts. The West African humid region, with its abundant grazing resources and market potential, is a particularly favored destination for MLFs. Even sedentary pastoralists often provide shepherding services to emerging local livestock owners. Despite their pivotal role in the livestock production system in the region, MLFs face challenges in societal integration and accessing essential social services including animal and public health services. With a low regional livestock vaccination coverage, unregulated animal movements exacerbate TADs transmission, leading to a high disease burden. The high disease burden contributes to antimicrobial misuse by farmers, leading to development of resistant pathogens in the food chain and public health system. Ineffective disease management further leads to high livestock mortalities, and associated mental health problems for affected livestock farmers. TACHLE aims to understand the living conditions and practices of MLFs that facilitate TAD risks in the livestock system, and identify mechanisms through which animal and public health services could be enhanced for better wellbeing of MLFs, and public food security. By working with mobile communities and local authorities in Ghana and Cote d’Ivoire, this project will bring together the expertise of a consortium of human, animal, environment and social scientists to enhance TADs control, and evaluate innovative, user-friendly tools to improve MLFs’ access to routine health services alongside mental and nutrition health services. We will additionally develop research capacity in the partner countries in integrated and transdisciplinary research approaches, supporting the development of early- and mid-career scientists addressing TADs.