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Institute of Diagnostic Virology (IVD)

Laboratory for Biocuration

Today the scientific community produces more data than ever. New methods and technical progress make it possible to store and share theses data. New tools are necessary for a useful exploitation of these data but also assurance of data quality is a prerequisite for any reliable analysis result. The Laboratory for Biocuration works on methods for data curation and puts them into praxis.

GISAID EpiFlu™: Data curation of an Influenza sequence database

GISAID EpiFlu™ (www.gisaid.org) is the world’s most comprehensive publicly accessible database for Influenza sequence data. The technical hosting of the database is realized by the Federal Office for Agriculture and Food (BLE). The Friedrich-Loeffler-Institut carries out scientific plausibility check.

The curator develops and applies new concepts and methods for quality-based data processing together with software experts.

Research Projects

Ad-hoc-de-novo-detection of viral pathogens with adaptive diagnostics for the prevention of epidemics (DetectiVir) : Optimization of in-lab and in-silico methods for metagenomic virus detection

Deployment of a generic diagnostic workflow based on next-generation sequence information and new integrated bioinformatic database approaches for the direct detection of new viral pathogens. The joint project combines molecular nucleic acid-based virus discovery by metagenomic sequencing with ad hoc development of customized serological diagnostics. An integral part will be a new and innovative database application.

The project DetektiVir is a colloborative project within the framework “Civil Security” (www.sifo.de) funded by the BMBF.

The FLI provides the data platform for the Users at https://detektivir.fli.de.

One goal of this collaborative project funded by European Union Horizon 2020 program (www.compare-europe.euis to harmonize deep sequencing methods and workflows as a prerequisite for their usage in clinical applications. One of several projects is a pilot study to compare sequencing workflows in a ring trial with samples from three European H5N8 Influenza outbreaks.

In a joint approach with the Reference Laboratory for Avian Influena : Methods for pathogen characterization by deep sequence population analysis.


Link:

OIE and National Reference Laboratory for Avian Influenza / Fowl Plague 


In a joint approach with the Reference Laboratories for Swine Fever : Deepsequencing of clinical swine feces for pathogen detection and identification of coinfections. 


Links:

National Reference Laboratory for African Swine Fever

National Reference Laboratory for Classical Swine Fever