Infections with viruses in particular usually produce an adaptive immune response. In the laboratory for adaptive immunity, the mechanisms of such an immune response are investigated in various acute infections and after immunization. The focus is on the reaction of T lymphocytes and their effector mechanisms.
A wide range of pathogens is studied, but particular attention is paid to infections with influenza A viruses, African swine fever viruses (ASFV), classical swine fever (CSFV) and Newcastle disease virus (NDV). As natural hosts, domestic pigs and wild boars and various poultry species are studied. The mouse also serves as a model organism.
In parallel, we are working on a tumor immunological project in the mouse model. Here the oncolytic potential of the Newcastle Disease Virus (NDV) in pancreatic tumor diseases is investigated.