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National Reference Laboratory for Crimean-Congo hemorrhagic fever virus (CCHF)

The Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is transmitted to humans by ticks and causes Crimean-Congo Hemorrhagic Fever (CCHF). Infections in animals are  asymptomatic (except ostriches).  CCHFV is endemic in Asian, African and Southern European countries. The distribution of the virus in Europe is closely linked to that of the vector tick Hyalomma marginatum. CCHFV belongs to the order of the Bunyavirales, family Nairoviridae, genus Orthonairovirus. CCHFV is classified as a hazard group 4 agent and handled in containment level 4 (BSL4).

The virus is detected in humans and animals from blood and other clinical material during the acute infection phase by qRT-PCR, cell cultivation or inoculation in newborn mice. Serological detection of specific antibodies is possible. Laboratory diagnostics should be performed at the Bernhard-Nocht-Institut für Tropenmedizin (consulting laboratory) regarding human cases or at the FLI (National Reference Laboratory for CCHFV Infections in Animals) regarding animals.